I own a Chevy Nova myself but love All American cars. There is this poll I just found that gave the choice of the three giants: GM, Ford, and Dodge.
You can vote yourself at the poll

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Depends more on the model than the make.

Example would be the dodge neon pos version and the SRT-4 version which is the car on steroids and made to last.

I actually drove a Neon for a while (new that year) and it lasted for 30,000 miles with out any hard driving and it started having major transmission and engine problems.

In general I think the best quality cars seem to be GM. Dodge would come next with ford in last.

I think for passenger cars, I would go for the Chevy, and for trucks and pick ups Ford. I don't really fancy the cars produced by Ford. I like their lines for trucks and pick ups specially the older lines. I wish I could get an old Ford Pick up, any model and be able to fix it up...

First define what an "American Car" is! Many "Big Three" auto makers just slap on their nameplate on imported cars.

There are no Completely "made in American" cars since AMC went under. They are all a mix of of internationally made parts and many GMs and Fords anyway are assembled in Canada or Mexico - would those count?

There are better and worse models by model year so it's hard to group them all together,

T
Tom Greenleaf - MetroWest Boston - USA
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http://www.autoacsystems.com/tomgreenleaf/

I can't count the number of times over the years that people have asked me this same question. Or which car is the best to buy. Which will last the longest.
I finally came up with the correct answer about 10 years ago. My answer is: The best cars on the road are those whose owners keep up with the maintenance schedules religiously.
Until around the mid ninetys american cars were still being built on 1960's ideas. they just wouldn't last long. mabe 150K or so before major work/repairs were required. Since then the internal engine specifications have tightened up to the point that american engines are as good as anyone else's SO LONG AS MAINTENANCE IS NOT NEGLECTED!!! Even the jap cars would fail in short order if maintenance was ignored or neglected. Ok, so we're all here because we care about our cars and want to take the best care we are able of them. The above paragraph was mostly for those who wait until their oil light comes on before opening the hood...and never change the oil.
Of the american cars i have found the following: Ford has the most advanced control systems in the world. GM is the most user friendly. Chrysler, well; they are just chrysler...i did like the old 2.5L four cylinders - easy to fix. computer controls were pretty much garbage though.
SO, if one is well versed with ford systems; then they have a pretty good vehicle. Not, however, my choice.
GM is my pick for the best built american car. the small block V-8 has been around since the 50's and the 4.3L V-6 is nothing more than a 350 small block with the back two cylinders chopped off. The 3.8L was a great engine and the other V-6 engines always had pretty good reliability. I just wish they would get their act together concerning gas mileage though!!